Another thing to consider with it is (don't worry I've had the same thoughts before of putting 416 axles under the canter...), the truck will be 4" higher without changing anything else... You can lower the suspension some to accommodate, but then you're gonna be getting real close to either the chassis or the sump or both, and probably don't want any less than 2.5-3" of compression travel otherwise it'll ride like crap..
Mogs have curved chassis to account for the height of the axles + susp travel.
Sure portals are cool and nice to have, but I've never seen anywhere where big tyres haven't provided enough clearance. The lockers are a must on a truck though (imho)- you don't have the option of using momentum to bounce over stuff..
Reduction hubs (portal or planetary) are nice sometimes- especially with big tyres. But do use slightly more fuel than a direct drive.
Maybe see if you can find some MAN or merc planetaries?