Steve Frisbie built an awesome Suburban and it looks set to tackle any trail.
I haven't seen the new bodystyle GM's used as an expedition platform. The late 80's and early 90's Subs are seeing a resurgance in popularity for those who want to drop in a Cummins. There was another write up recently about a guy out of Grand Junction I believe, who had dropped a Cummins in an 80's model Suburban. The pics of this rig on SW Colorado trails were impressive. Stout axles, t-case, diesel power & torque with gobs of passenger room. Looked pretty slick.
I'm going to agree with Scott, that some of GM's trannsmissions, like the SM465 is not GM's best transmission. However, IMO the best part of any GM is generally their tranny's. The 700R4, TH400, NV4500 and the Allison, are all excellent tranny's and it's hard to dispute the popularity of GM's 350 & 454 engines. Parts for those are everywhere. And as Aaron mentioned, a 42 gallon stock gas tank will offer quite a long range.
The Duramax diesel has not been offered in a GM SUV, only their 3/4 and 1 ton trucks. However their old 6.2 and 6.5 liter diesels were available in the Subs, Blazers and Jimmys. The 6.2 is a dog but it was used by the military for a long time and there are still a few running around. They will also run at any angle, and with the short wheelbase of the full size Blazer, it makes for quite a good trail rig.
The problem I had with my full size '89 Jimmy (and it would be the same with a Sub or Excursion) was trying to see over the hood on an incline. Like many things,
there are several die hard full size GM fans who run their K5's over the toughest trails in Moab.
One of the 4x4 mags in the last year or two, was building a late 60's 3 door model Suburban. They documented the t-case and axle swap, lift and a few other things. Haven't seen an update in a long time on that one.....?