Depends entirely on the van and the lift.
Sorry that it's such a trite answer, but there are entirely too many variables.
Comparing just a single platform like the Econoline, there are excellent lifts and 4x4 conversions (which generally necessitate a lift) from a number of companies, and there are other 2WD lifts and 4x4 conversions that handle like the worst kind of buckboard-wagon you can imagine. (I've driven and ridden in both.)
My smaller Astro van has a very mild lift of ~4" using mostly OEM parts (factory-spec rear leafs with a 4" taller arch in the rear, and 2" body pucks + 2" adjustment to OEM torsion setup in the front), and it handles very close to OEM, except for being taller. It's been a long time since my van was in the ballpark of factory weight (pre-camper conversion), but my impression back when I made the change was that it felt unremarkable - i.e. no appreciable change. My van is small enough to be daily-driveable, but with taller tires, it took spending $$ for a re-gear on the axles to get the fuel mileage back into an acceptable range for anything but recreational use.
That said, comparing a 4x4 or lifted van to a Jeep is very apples and oranges - vans are taller, so the even empty they handle differently. I've never heard someone complain of a Jeep getting pushed around in the wind, and very few vans are going to make capable rock crawlers. When I daily-drove an XJ, the cargo room was "enough", but being able to stand up and move around, or throw a seriously huge volume of cargo into a van is sure nice, and nobody but Justin Pitcairn is going to sleep 3-4 people in a Jeep.