My neighbor (well x-neighbor, he moved last month), as a 96 F250, that he converted the front to a 1 ton suspension/axle combo, and it has a 4" lift. With wider heavier duty wheels, and wider 10 ply 36" tires, his rig handles his 10' S&S camper great.
Something we noticed this summer.
Out here in the PNW (ie OR, WA, ID) , truck campers (slide in's) are more popular than we saw visiting states East of the Rockies. Once we dropped out of the Rockies, and ventured across the plains, all they way to Tennessee, down through Alabama to the gulf, and back west to Texas, we didn't start seeing truck campers in numbers again until we were in Northern New Mexico, and headed back up through Colorado/Utah region.
Out here you will see every combination of truck with a slide in camper you can imagine. Some are pushing the limits, some are barely tapping the potential. The great thing similar to towing a travel trailer is you can always change either the truck or the camper down the road as your needs change.