20inch is not too bad of a size, tires are easy to come by, basically you are looking at the same size tires as a Unimog, like charlie said I would not go above 335/80R20 as they start to get very heavy the ford is going to start having axle problems as well as brake and unsprung weight problems.
There are lots of tires available, such as Conti MPT80,MPT81, Mich XL, ZXL, XM27, XM47 etc. Most tires in this size are only DOT legal to around 60mph, a couple of them 70mph, if you need to drive faster than that these may not be for you. Like I said above, with tires this heavy at 70mph your suspension better be ready for a beating, the same goes for driving on washboard.
Rob