The vehicle weight definitely matters.
+1 more...
I think the worst case for a transfer case in a heavy vehicle with a long wheelbase is simply turning in 4wd. Even on gravel or dirt, there is going to be a LOT of windup between the front and rear drivelines, which would ideally travel at different speeds in a turn, but are locked together by the transfer case. It's amazing the difference between my regular cab and extended cab trucks in 4wd. The reg cab turns much more easily, and needs to slip tires noticeably less than the extended cab does. Our 4wd crew cab dually brush fire truck will pretty much stop if you try to turn sharply in 4wd even on a gravel surface.
I had been considering making my C60 dump truck 4wd for a while, as I used it in the winter for snow plowing in our community, with plenty of hills. It's low power, so I wasn't worried about cooking the t-case, or snapping a shaft with torque, but I was really worried about binding in turns, since the wheelbase is long and the truck is pretty heavy. To combat the binding, my plan was to use a 203 divorced case. That way I could leave it unlocked in most conditions, which would preventing any binding and ease turning, and if I got hung up somewhere and it was only spinning a front or rear, I could lock it in at that point and hopefully escape.
In the end, I found reduced tire pressure, a bit of weight at the back of the bed, and occasionally a set of tire chains sufficient to get the job done.
As for large truck t-cases, you might consider using an air shift transfer case out of a M35 A2 or A3... I believe even the A3 was divorced mount, and it has synchronized shifting, so you can shift the truck trans to N, and shift the transfer case between high and low range at any reasonable speed. Low range is 2:1, but that's usually plenty low for larger vehicles with transmissions that also have lower "low" gears. The air shift engages/disengages the front axle, and you could probably convert it to cable actuation. Additional bonus is 2wd low, for tight maneuvering without bind.
Just a thought...