Which battery do you mean by 'target' battery (start or house)
The battery that the charger is intended to charge.
That kind of leads to understanding what you're doing in more detail.
Are you charging a stand alone house battery or are you talking about your main starting battery that's serving dual uses? Or trying to charge two batteries?
If you're charging your main battery then you can't completely ignore the chassis ground. You might still want to run all the way back to the negative, though. If it's a house battery powering it's own loads then it's easier to run both a positive and negative between the charger and be done with it. Just use the battery negative as a common point and don't tie to the truck chassis at all.
When you say truck camper is it a slide-in that's basically isolated or are you talking about a camper shell where the loads are actually body mounted (e.g. things like metal cases being actually in contact with the truck body)?
Most likely the engine block is the common ground point for your truck's electrical system and trying to use the chassis as a reference or return for added electrical can come with challenges.
Sometimes you have no choice to deal with it, such as mobile two-way radios with body-mounted antennas. In that case you will have the body tied to electrical returns whether you like it or not.
Other times you go to lengths to avoid it, such as 120VAC systems that must have complete ground isolation from the chassis. Sometimes using the chassis is a convenience and you figure out a way to do it successfully.
In any case you need to be intentional, either commit to it or do not.
What he's suggesting is it's usually easier and introduces fewer issues to provide complete return paths for all your add-on chargers and loads instead of relying on a common one such as your frame and chassis.
The term you're referring to is ground loops or ground sneak paths. These happen when you mistakenly provide more than one way for current to get back to its source. What happens is your normal return/ground develops resistance and that creates problems itself or leads to current trying to find a lower resistance path. This might be lower in resistance but not large enough in size to handle your maximum currents or worse with respect to RF (in the case of radios). It might cause alternator noise on your radio, excessive voltage drop that leads to poor charging or in the absolute worst cases melted wires or a vehicle fire.
By running a dedicated, properly sized negative from your charger to the battery you're charging you just make things more simple.