I think the terrain you are travelling is the biggest factor.
I come from a rock crawling background where aggressive tires are required. I've tried numerous different radial MT design tires. With my mad driving skills:smiley_drive:, I can take out the side wall on a radial MT in 10 feet!
Interco TSL/SX's are the only tires that have met my needs in the rocks. Awesome tire, damn near flat proof, can be aired down below 5 psi with few issues. Would I run them on my LJ for overland type use? No! Well... I'm hard headed... I have put them on for a few cross country trips.
For my use, Death Valley, Baja, SoCal deserts, BFG AT's are the best all around compromise for my use. In overland style travel I've never encountered any terrain where the AT style tire was my limiting factor. Having said that, I rarely see any mud. On the rare occasion that I do encounter mud, desert mud is like peanut butter. There isn't a mud tire out there, including Bogger's that it won't clog\ the tread on.
Look at the tires that others in your area are using with success and go that direction.