E85, 85% ethanol. Ethanol has about 50% of the energy content by volume as gasoline. Therefore, it'll lean it way out. It'll also eat seals, and the aluminum intake over time, which is why you don't want to leave it in there long.
Even using E10 would help, if you normally run pure gas, E10 will run about 5% leaner.
If your O2's are bad, which is why you're running rich, then the engine will adjust and add 5% more fuel, getting you back to running rich. With E85, I doubt it can even adjust that far. Of course it might set a code too.