The engine and drivetrain on these trucks are extremely reliable as a daily driver. In my ownership experience, the primary thing to be aware of with the 4.7L V8 motor is a proper water pump & timing belt service performed reasonably close to Toyota's prescribed service interval. This must include a new thermostat, tensioner, cam seals and all the fixings. The next big thing i noticed is these engines can be sensitive to improper oil change intervals. Wait too long and the timing and ignition will suffer. The final consideration i'll mention is one I've personally experienced, and that is the ever-common cracked exhaust manifold, caused by rust most frequently present in Midwestern & east coast vehicles where road salt takes a toll. $1300+ for OEM Manifolds plus ~ $500 in labor if you're lucky. $850 for Doug Thorley replacements plus labor to install. Ouch.
Ditch the air suspension. More than likely, if you're a member of this forum you'll outgrow the stock suspension after a season or two. Reliable aftermarket shocks & springs will support and level a ridiculous amount of weight and If you need rear airbags for towing heavy trailers, you can install a set for $100 without fiddling with OEM electronics and light duty equipment.