My two cents from wheeling a 1999 F250 SD for almost 10 years.
Lots of issues discussed here and applicable wheather you are running the dana 50 or 60...
Front is vacuum actuated - issues with loss of vacuum to holes, leaks etc. Additionally, the V10 and older diesels sometimes have issues with low vacuum, so you can see random disengagement.
272 transfercase is shifted via electric motor - cannot be modified to manual shift without case modification and this would void your warranty. Additionally, though this case (in it manual form has a neutral) it is not advisable to flat tow as this will create havoc with the internal oiling system.
Changing out to an Dynatrac or EMS hub replacement solution would solve a number of issues - Unit bearing are inherently weak when lateral preassure is applied to the unit, susceptible to water, mud & gunk. Additionally, due to design constraints the front axle is small and susceptible to breakage. These kits will replace the stub axle with a larger diameter unit with 35 splines (important if you user an LS or locker). Additionally with the stock setup you are limited to a fairly small tire size. They are pricey and when they fail, thats it, they can actually sieze and break your axle. Oh yeah! The factory hubs will also grenade on you when you apply multi-directional load to them, (ie., tire stuck between two rocks and climbing out).
Why a unit bearing? The decision to migrate to a unit bearing was a concession to the manufacturing processing, they are quicker and easier to install at the factory and setup.