I've done it, it works. Did it in my 'glass buggy instead of a spare as we were rarely more than a day from base camp. The thing that you have to have a remedy for is a catastrophic tear in a sidewall.
Need some way of getting the valve stem out, and a bead breaker. I used motorcycle tire spoons. While short, they were light - a primary consideration in a low power light vehicle. As a test before the first trip into the field like this I installed it's then new 31-10.5 BFG A/T's by hand using those tools.
I built a bead breaker that used a short section of chain with a lug bolt welded to one end, and the 24" Snap-On 1/2" drive breaker bar that I always carried for leverage. The bar went in one end of the breaker and the chain fit into a hook on the other end. This meant that the wheel & tire did not have to come off of the buggy. Was actually preferable that it did not as that gave you enough to pry against that it made the whole job pretty easy.
Some baby power to roll around inside of the tire just before putting the tube in is a good call too.