? I am now realizing that what I’ve seen in those builds is usually just an aluminum channel that the panels fit into. For some reason, I was imagining an aluminum frame.
Some might use an aluminum extruded channel that the panels fit into, but that would create a thermal short (aluminum thermal conductivity is very high). The simple way is just angle inside and outside of corners. You could get say 1/16" 5000 series aluminum and press it into any angle you want for more interesting shapes rather than 90 degree square corners.
I'd planned on using idaSHO's construction approach of frame, then glue and plywood. Mostly because it seems like it would be far easier to join walls and install doors and windows that way versus having to cut them out later.
Oh no, if you are making ply-foam-wood panels, you build all the openings in as you go. For instance you'd lay out and screw and glue the wood "framing" on your concrete floor first, or huge table if you want (plastic sheet underneath). Then cut and glue the foam pieces in place. Next glue and press one plywood side (use screws too where you can). Flip it over and do the plywood on the other side. If you are going to use fiberglass on the exterior (highly recommended), it's best to do that on a horizontal surface also.
You'll get a better bond this way. Bonding on the vertical is iffy because you can't apply pressure. Not to mention bonding the bottom sheet for the ceiling! But if you make panels and join them, you'll need to move them around occasionally, so you'll need room to do that and a helper. I made a thing in my garage where I could store panels upright and ~2' apart so each could be moved without messing with the others.
Basically, if you have room and a helper, I'd definitely make panels. If you are cramped for space and working solo, then framing is probably the way to go. Bonding gets way trickier... but maybe it's a case where the wood in the core supports the skins well enough even if the bond to foam is uneven?
1.5" core is fine, but 2" would be better R value and stiffness, and where I live 1.5" isn't available. People who build big campers with composite panels usually have at least 3" roofs for stiffness and R, but I'm sure 2" will work. The floor will be supported on a flatbed, yes? Not much is needed there, so it really depends on if you want to use it when raised up. It will be strong enough, but maybe a little bouncy.
Make that sample piece I mentioned. Also buy some epoxy (I like Ebond's cheap stuff, slow cure), and cloth (6oz? plain weave) and see how much more durable that makes the skin. Compare it to just an epoxy coating.
Definitely use at least 25 psi foam. I can't believe it's over double what I paid 4 years ago! In fact unless you are really poor I'd go ahead and get PVC foam from Carbon Core. It's about 3x the price still, but it's 5x as strong too, and it's easier to bond.
The seams? You should have solid pieces of wood there, screwed and glued together. Very solid joints.