Here's the replacement for the Ford Escape in 2012, as shown at the Detroit Auto Show. This concept vehicle is called the Vertrek. Ford may decide to continue using the Escape name for the production model. I assume the production model will have smaller rims, and door handles!
The Vertrek is based on the Focus front drive chassis, and will employ Ecoboost 1.6L and 2.0L four cylinder engines. Compared to today's Escape, the Vertrek is a couple of inches wider and longer. The roofline is definitely lower, and tapers toward the rear to improve aerodynamics.
There's no word yet about AWD, but the Vertrek is supposed to be Ford's "all weather, all road" compact crossover. So I expect some way to drive the rear wheels will be optional.