Bigger tires are heavier... It takes more torque to accelerate them as quickly as the smaller tires.
If you calculate out that you need something like say 4.20:1 ratio to keep a stock ratio don't go down to 4.10, always go up which means with our trucks 4.56 since that is the next ratio available for both the front and rear axle. Also, this gives you that extra little bit of extra torque to deal with the weight of the tires.
When you calculate your cruise speed the difference between say 4.10s and 4.56s will be ~200 RPM. Is that
really a big deal? No. And, like suggested, it won't hurt our engines. Will it make a difference "hyper-miling" at cruise? Possibly, and I wouldn't lay money on whether it was a good thing or bad.
I did the math this morning of how much weight I'm adding to my XJ. ~700lbs. Even if I'm out to lunch with that number, lets say 2/3 of that is correct, we are still talking ~450lbs. Go with the lower ratio to compensate for that too.
Tall trucks have crap aerodynamics. Go with the lower ratio to overcome that too.
I've heard people say our engines like to rev. I suppose that is a true to a degree. It's no 9000 RPM Honda engine but I've never noticed any extra vibration up to around ~4k RPM or so. Beyond that engine speed it is an annoying engine. Hey, it's an antique cam in block engine so it does well for what it is. I personally wouldn't want to be cruising at 3000+ RPM.
IIRC with 4.56 gears and 265/75R16 I'm going to be turning ~2650 RPM (to lazy to calc/verify) at cruise. I'll eventually be going to 255/85-16 as my next tire size. That'll drop a couple dozen RPM at cruise as well.
Once I get this thing done I expect I'll play with it highway speed to determine what is the best cruise speed versus comfort level versus mileage. My gut says it's going to be around 110-115 km/h. A balance between feeling like you are actually going somewhere, not watching the gas gauge drop too quickly and noise levels.
FWIW, my 2001 Sport came with 205/75-15 tires. OEM crappy GY Wranglers.
Anyway, back to welding the TNT stiffeners on.
HTH