Quick notes:
Regular F150, most have 8.8 IFS front axle, super 8.8 rear solid axle.
Some F150 have 9.75 rear solid axle.
To have over 2200# payload you will need a 5.0 or 3.5 with very specific options/build package in a lower trim truck. Ie max payload or max towing or both.
The advertised fuel economy is usually not for higher trim 4x4 trucks. Usually XL or XLT with no add ons.
The empty fuel economy and the loaded up fuel economy are nowhere near the same.
Putting larger tires, small lift, removing air damn etc notably lowers fuel economy.
I'm running a 2014 F150 XLT 300a with 3.7 V6, 1.75/1" front/rear lift. 34" inch tires in load D, a topper, skid plates and assorted daily gear, and I struggle to tow a 5000# camper with any sort of hills and get 20 liters per 100km when doing it, or worse. With a 91 octane tune.
To be fair newer truck same set up would weigh less due to aluminum.
I would literally get the same or more ground clearance with an FX4 super duty. I would likely get very similar fuel economy while towing, judging by guys towing similar/heavier stuff.
If you tow and haul seldomly, getting a max payload/max tow f150 will save you a bit upfront IF you can find one, and save you a bit on fuel when not towing or hauling. It will also drive nicer unloaded and handle a bit tighter in town.
But once you use it under load, kiss most of those advantages goodbye.
My associates 2.7 EB costs 4+ liters per 100km with its cap, roof rack, ladders and tools/gear inside on STOCK tires, height, etc than when empty, for reference.