Too many variables to have an honest mpg number except specifically for your rig. I'm suspect of anyone with a Gen II, H.O. 5.9L Cummins to get better than an empty 20 mpg. My all time best was 19.8 mpg, hand calculated. (505TQ/ 245HP/ 6 speed manual/ 3.55 gears/SB/XCab) This drops to 13-14 with my small Lance Camper on board. The general bottom line is: the 2500 or 250, 4WD, diesel will get the best mpg when it's in it's original state with tiny factory sized tires/wheels and no add ons. If you add a 'wire' you can eek out a little better mph with the lowest hp setting, and it's a slug, but that is window dressing, as the mpg drops like a rock when you change the timing, add bigger injectors or increase the fuel rate, and are followed by a billowing trail of black smoke, and it runs hot. Another observation is that a diesel, at least the Cummins, gets better mpg the slower you go, even hours at or near idle, because the torque keeps pulling all the way down to zip. On trips both ways on the Mojave Road, we drove for 4 days, at about 15-20 mph using what looked like less than a half tank of fuel. The needle slowed way down as we slowed down for the road surface. This does not happen with a gas engine. With the camper on, wind resistance had something to do with it. The real question is how long do you want to keep the 2500/250? If in it for the short haul, a gas engine will pay for itself with no 'diesel penalty' which has now grown to over $12000 for the oil burner. If you want to keep the truck for as long as you are on this earth, a diesel will finally pay for itself after maybe 250K miles or so. In the same vein, if you have a penchant for periodically trading up or down or sideways with your 'project' rigs, go for the gasser. I"m in it for the long haul and bought my 2001.5 Dodge Ram/Cummins H.O., new when they did a big upgrade on the drivetrain figuring the truck with a Cummins and much sturdier manual trans and Dana 80, 35 spline rear end might just outlive me. So far, so good @ 164K miles.