I don't know about the 2nd gen, but I agree with everything Haolepinoy said on the Gen III. The biggest issue is getting to the backseat if you have carseats in the middle seat. Depending on how big the carseats are they may not even fit in the back seat. I also have a beef with how they set up the Latch points on the second row, but the seat belt works well enough. For people with short legs the 3rd row is passable, but for everyone else it is a bit snug. You'll also find that your back springs are probably shot - after a couple hours in the back of my Gen III my wife finally ok'd the new springs from ADD! We've only got 2.5 kids, but I already have plans for a minivan for non-adventure duty.
An additional consideration is how to carry stuff when you're going on adventure with all those kids. The Gen III just isn't all that big of a vehicle, so unless you are going to add a roof rack, tow hitch rack, or tow a small trailer it's tough to get all your camping gear in it with several children...
I will say, one nice advantage of the third row in the Gen III is that it's stupid easy to remove, and it stores pretty easily. The 2nd row also comes out with like 8 bolts if rolling them forward isn't enough. This means for solo/duo type hunting trips it can be pretty voluminous inside. I carried a cow elk home last year inside the vehicle with tons of extra space for camping gear etc.