I have some MRAP aluminum wheels, Hutchinson part # 1326. These are 10" rim width, 4" offset and weigh 75 lbs.
I believe your F550 rear axle overall width is 74".
The center in these wheels is 1" thick, so if you mount them with the "big dish" out, plus the center thickness, plus say a 1/2" adaptor you get an effective offset of 5 1/2" (4 + 1 + 1/2).
This means wheel centers at 85". Plus width of 335/80R20 (13") means 98" overall width.
If you mount the adaptor "inside" the wheel, then the offset would be 4", so overall tire width would be 95".
Note also that in normal duals, the load on the axle bearings is "centered" between the duals, at axle width, 74". Going wide singles moves this load out to the center of the new wheel - about 85" or 82" depending on the way you mount the spacers. This will put added load on the bearings.
Not sure what front axle overall width is, but say 90" for sake of calculation (substitute actual number).
Mount wheels "big dish" in, with 1/2" adaptor plate gives offset of either 3 1/2" (4 - 1/2), or 5" (4 +1" center thickness) depending on which side of wheel center you bolt adaptor plate.
So wheel centerline would be 90 - 7", or 90 - 10". 83" or 80".
Add tire width of 13 gives 96" or 93" overall width (assuming 90" overall axle width).
I think this calculation is right.....
I think the Alum MRAP wheels at 75 lbs are not too bad. These are the ones with the CTIS (see link). The stock steel wheels are about 65 lbs (but don't forget the additional weight of the adaptor....)
There's also a heavier wheel at about 90 lbs.
https://www.ebay.com/itm/20-X-10-MR...MILITARY-4X4-6X6-CTIS-WHEEL-RIM-/182740568762