Final note, why does every "Overlanding" thread degenerate into a mud bogging and rock crawling discussion. Overlanding in America is much more improved road surfaces with the occasional rugged terrain than the opposite.
Perspective.
When people ask me about the best tire, I think about where I off road. Which is the southeast. We have mud here. Unless you stick strictly to groomed fire roads (there are plenty around here) then you need them. No question about it. Now if you are sticking to the groomed fire roads, heck you don't even need to modify your truck. But 4WD low would be extremely helpful.
If you watch the weather (this past year, it was unavoidable, it rained every week), you can get away with an AT or a Duratrac but you gotta be careful. If you wheel anywhere in the swampy areas (closer to the coast and a significant portion of Florida) an AT is pretty useless. Having seen trucks slip and slide all over the places and simply cause more issues, that is a problem.
Also for the southeast, you really gotta go to parks to actually "wheel". Sure there are a few roads around you can hit up but the parks offer a one stop shop. Once again, only MTs is what people bring. You need traction in these places. Also the shade from trees keeps trails sheltered and they don't dry out. I've seen trails that haven't seen rain in 4 days be all kinds of misery once they get in the tree line.
Outside of the southeast, my statements are invalid. I've heard that the tires that I recommend for the southeast are crap in the snow (as I've been told by my upstate NY friends). Inversely, the tires that are crap here are are epic up there. Just an example of regional tire knowledge.
What do you need out west? No clue. Never wheeled out there. However I'd like to one day.
Always think regionally when making these statements. Just because it is good here, doesn't mean its any account elsewhere.