Yes. I run a bunch of icom gear that is all dstar enabled.
Mostly, it's to eliminate static when we are still en-route. There isn't much interference in the wilderness so audio quality generally isn't an issue while remote.
I don't think I really gain much, but the gps-subdata has been useful a total of two times. It saved us a few minutes of reading the coordinates.
Mostly, I chose this hardware due to icom's gps-aware dr memory that allows you to "find nearby repeaters" from the programmed list of 1500 repeaters, in conjunction with the ability to page in/out pages of 1500 programmed repeaters to/from the built in SD card. This functionality allows me to use "find nearby repeater" anyplace in the western United States with every repeater on repeaterbook programmed in.