2021 F-350 4x4 DRW RCLB pickup with 7.3L gas engine and 4.30 gears, maximum conventional towing (bumper) is 20,000 pounds. 28,000 GCWR.
2021 F-450 4x4 RC chassis truck with 7.3L gas engine and 4.88 gears, maximum conventional towing (bumper) is 17,500 pounds. 28,000 GCWR.
2021 F-550 4x4 RC chassis truck with 7.3L gas engine and 4.88 gears, maximum conventional towing (bumper) is 18,500 pounds. 28,000 GCWR.
The towing capacity for the 7.3L gas engine is pretty good, but, for heavy payload combined with heavy towing, the 6.7L diesel engine would be a good choice with the much greater GCWR.
The chassis trucks listed above have the same maximum conventional towing (bumper) with the 6.7L diesel engine. To tow more with the diesel, one would need to go to 5th-wheel/gooseneck.