I'll chime in.
The weight will be the biggest difference. In my experience, a higher load rating does not actually confer greater resistance to punctures. In the old days you did have more plies (10, 12, 14 ply, etc), but tires aren't made that way anymore, even if they still label tires that way. I would say that if you're willing to suffer the extra weight, going with a load range E tire to get the profile that you want is fine, but don't think that you're getting a "tougher" tire.
Our Monty is armored and not lifted and we overload her mercilessly, so we drag and grind all the time. The lava in central Washington is as jagged and as nasty as you can imagine, and our Les Schwab AT (load range D) tires look like they've just come from a knife fight after driving that stuff. But no punctures, no sidewall cuts.
OTOH, on our last trip we encountered a guy who had just had TWO flats in the same day, both times with load range E tires on his big F450 fifth wheel rig. Both culprits were pyramid-shaped rocks that simply punched through the center of the tread. We drove hundreds of miles on the same gravel roads and our puny little load range D tires were just fine. His bad luck, our good.
Any tire can suffer damage if the rock or foreign object has your name on it. Get the tire that you want and enjoy the heck out of it. And carry stuff to repair your tires! There's a cowboy in Idaho who's our friend for life after we rescued him in the middle of BFE with our tire repair gear and compressor. :sombrero: