I realize you want Ecoboost specific info, but I opted for the 5.0 after driving both, and at the suggestion of a few here on Portal. I am glad I did- better entry price, very near same economy, no 'turbo/electronic controller' concerns. For mid $30's OTD, XLT 4x4 w/ rear locker and camera, tow mirrors, power pedals, etc- pretty decent truck. However, it became a 'truck' once the P rated tires were swapped out for E rated LT tires, front leveling kit, and rear airbags. I have towed 8k# a couple thousand miles through the mountains( east coast...) and have no regrets.
I had a 250 replaced by Ford back in '03 being one of the first with a 6.0, and chose not to go through all that again. However, I did gamble on an '11 250 with the 6.7, as I felt Ford could not afford to mess up another diesel, and it was amazing!! My needs have changed, and the 150 is adequate with the CC & 6.5' bed- I am a happy camper so to speak!
Hope this helps, and the family likes this setup as well- two kids 6&8, and plenty of room!! More rear seat room than a 250!!