My hallmark is set up that way now for the forward tie downs. Getting to the driver's side forward tie down would not be easy for someone of larger build, but I manage... The rear tie downs go to my rear bumper, as there's no good way to get into the tighter space where the camper is wider behind the wheel wells.
I also use a ratchet strap on the front tie downs now, as I find they loosen less than turn buckles, and are more forgiving of the camper moving a little. I run them in an upside down "V", with both hook ends going to tie downs I've added to the truck bed.
I still use turnbuckles and chains on the back, as they're easy to get to, but I added a wing nut to each turnbuckle so I can "lock" them from loosening further if the camper moves a bit and slacks the chain up.
Pics in build threads in my sig...