Deciding on the base truck is always a compromise, you need to decide what you want to do. Getting the biggest 6x6 truck so you have a mobile palace might be what you want, but that means getting to a lot of places will just not be possible, getting a small truck means you have a lot less living space but it can get to the same places as the Land Cruisers and Jeeps.
Consider that for small vehicles, the truck will be close to GVM all the time, so you will be stressing the truck all the time, even on "bad roads" let alone off-road. The Fusos and Canters have pretty lightweight chassis, and as same with the normal 4x4s, like the modified Land Cruisers and Land Rovers with big campers on the back, they are just not designed to work at GVM on bad roads all the time.
If you get a big truck, you will probably not be close to GVM at all, so you can carry lots of toys. The truck will not be stressed at all, so should last a long time. Problem is getting it to fit into tighter tracks where only cars normally go. That often means that part of the truck get stressed doing thing it was not designed to do. I know a lot of people who bought big trucks, only to find they could not take them to the places they wanted to go to, so swapped back to a Land Cruiser and roof top tent.
I am of course very biased to Unimogs, especially the U1250s which are by far the best model of Unimog
That saying, I have modified mine extensively, probably more than most people would be willing or able to do, right now there are not many part of it are actually still from the U1250, come to think about it, very few are from the original U1250 I bought back in 2008. The chassis, RHD steering gear, the side windows, some of the gauges and and probably 3/4 of the cab and that's that's about all that is from the original truck I bought, but that is what I enjoy doing. We always get asked what would we change if we had to do it again, and like most owners, we always say we would not change anything lol, except I have changed nearly everything already. I always have some form of modification in mind, even if it just a little ones like an extra USB power socket, or figuring out a bracket for a 36" monitor. It is what I like doing when I have to work to get money to be able to afford to travel.
As far as the perfect best overlander, that different for eveyone, and is very dependent on your budget. MB seems are design the Unimogs for full GVM in bad or off road. That's the main reason I got mine, it is over designed for most normal use. I like going to the more remote places, and feel comfortable that my truck can handle a lot more than we would want to put it through, considering we have our home behind us. All trucks will break down, the more points of potential failure, the more likely it will happen. If a single faulty reading from a sensor stops your truck, and you have no way of finding out which sensor it is, or cant bypass something to get it going, then make sure you have the communications to get rescued. My own opinion is that if you can't fix your truck yourself, then don't stray any further from civilisation than your bank balance will enable you to get rescued from.
Everything is a compromise, but finding the right information before you buy the base truck is not that easy, everyone had opinions, based on their own experience or just what they have read or heard. I listened to the people who actually have trucks, and have traveled, rather than the internet gunna dos and wanabees that don't even go by their own name. Those people gave me their honest opinions based on their experience and I even listened to some of them