We've just left Pakistan after a month wandering around - key points:
- be flexible - we had to change route several times since roads were closed for landslides and weather.
- be alert to local advice and take it seriously
- plan on routes taking a lot longer than appears on google maps (and maps.me) - road deterioration, partial closures, and construction/reconstruction delays mean that it can take twice the time expected.
Lots more spring to mind but these are the top three.