One of the reasons we like building on 1-ton pickup truck platforms is they are designed to tow. We have a customer who also owns a Winnebago Revel, because the Revel can only tow 5000 pounds and when he wants to go out racing in the salt flats he needs to tow more.
We are a big fan of the new 7.3 gasser that Ford has introduced in 2020, but the big exception would be that if you plan to regularly tow with your F350 it might make sense to consider a diesel. You have to remember that the 7.3 is over 550 pounds lighter and $9000 cheaper - so you better be towing a lot to justify the extra cost and decreased load capacity!
I really like cabover trucks. Great visibility out the front and more cabin for a given length. I wish more cabover truck options were available in the US. A Mercedes 917/1017 would be perfect for my needs. What I really should do is accelerate my plans and buy Joe's truck, and go repeat the trip he just finished.