Absolutely yes, and I intend to. However not on a mid-size truck.
Here are some opinions I have.
-Gear storage. Both dirty and clean. You need separate locations to keep these things so your dirty gear doesn't come into you clean gear section. For example, your dirt camp chairs/snowboard gear laying down in the buildout inside your bed. It'll become such a hassle to clean and you'll get annoyed
-Comfortable seating, a kitchen inside the truck bed, and a toilet. These all take up tons of room and the 6.5' bed of a mid-size truck quickly becomes occupied
-Heat/cooling. It will get cold and hot. Having a way to battle these elements of nature is the only way to stay sane. Nothing like having extreme stomach poisoning in a camper, trying to battle that in 10 degree weather with no heat.
-A truck reliable, capable, and spacious enough to provide you with a good platform to live in. Your home is now on wheels, and when it is down, so are you
-A place to retreat to. If you randomly get t-boned or total your truck, you have to have a backup plan set immediately. When I think of living in a truck, I think of being off-grid constantly. If your truck breaks down in timbucktoo, gotta be prepared to get out of that situation.
-Ditch the tailgate and have a full back door. Fully seal every single hole in the bed and make sure it is 95% dust, water, and animal proof.
-Have somewhat of a home base, or a gym membership to a club that's nationwide. Hygiene is what you make of it, and it's not that big of an issue as some make it. Wet wipes, short hair, and less body hair go a long way.
Other then that, having a wedge camper equipped to handle every-day living is super important. Being insulated inside, having lighting, being constructed well enough to not break. No proprietary parts that can't be fixed from Home Depot or a fabrication shop.
I lived in my Vagabond Drifter on a Access Cab Tacoma for a month, and I loved every moment of it. My only complaints was that I had nowhere to put my dirty gear and driving the gutless truck was a burden. I moved to a Ram 2500 and have another Vagabond being made, and cant wait to move in. Best of luck to you and safe travels!