If you’re able to do the fab work yourself and wanting to run decent sized tires, a SAS isn’t a bad idea. You could probably do it for the same $ as a 6” drop bracket lift.
Ford Superduty axles are HP, driver diff, and can be commonly found for $500. If you get an ‘05+ it will be a Dana 60 and set up for coil springs and radius arms, which should be the easiest setup to fit.
Front Axle Specifications: 2004 - 2008 Ford Super 60 Coil Spring radius armstyle F350 Front Dana 60 axle with Reverse cut / High Pinion type gears and center section, 3.73 (41-11) gear ratio, disk brakes, open knuckle, 35 spline inner shafts, 35 (?).
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The radius arm brackets and coil buckets are riveted to the frame, so you could easily drill yours and bolt them on. If you’re interested I have an F-350 at my shop I could pull some frame width measurements for you to compare.
You’ll probably want to swap the matching rear in as well, both for strength and the matching bolt pattern. They use 8x170mm rather than 8x6.5”. There are Trutracs, Detroits, ARB’s, and OX lockers available for them.
The vast majority of them will be geared 3.73, but 4.10 and 4.30 were options, most commonly in the V-10 trucks.
IMO you don’t need a front locker on the east coast with a full sized rig. You’re much more limited by trees and switchbacks than the wide open rocks out west. Add a Warn M12000 and get after it.