Nope. Real solid truck. Body rust was the only downside to my 2008.
Lifts over 3" need exhaust mods or skinny drive shaft. Cut the crossover brace and realign the down tube. Remove the springs and work the suspension up to check. Bds is my favorite gas lift kit. Opt for the cheap shocks, get Kings later.
Don't back your exhaust into things, or it'll leak at the headers like a Gm 6.0.
Lube the front hubs and operate 4wd as often as possible, anytime you're going straight, to loosen it up.
Keep a spare starter handy and the tools to swap it.
You can adjust the sector gear to tighten up the steering, it loosens up with age. Make sure you have plenty of caster. More than the oem limits.
You can't spend too much on damping. Custom shocks with tons of rear rebound damping are nice.
Adjustable trac bars are nice. Jury is out who has the best one. Trac bars need to be in new condition and you need a huge wrench 20 feet long to torque the truck side bolt. Torque to complete retard strength.
I think 35's fit stock on a 18x9, +18mm, wheel. The obama sensors suck. I just put tape over that idiot light.
Don't fear the gear. 4.56-4.88 are great with bigger tires. Detroit or Yukon locker front, selectable rear, is my hot setup for big Fords now. The front axle is so locker friendly, it's a shame not to.