Let me get this straight...
You are worried about
Weight
wind drag
MPG
And you buy an ambo??
Didnt you read the FAQ?
Larger turning radius? NOPE. Try TIGHTER with the 4wd.
Lifting the rig to allow the solid front axle allows for a tighter turning radius.
Question: I'm working on a type II ambulance. Are the house batteries isolated from the starting batteries? ( 7.3)
I've got over 25,000 miles on Forest Service Roads in 2WD, and don't need 4WD. I admire U-Joint kits, I just don't need one.
All of my 4wd ford vans had a worse turning circle than my 2wd versions (2 Quigley and 1 Advanced 4WD). But my 2wd Freightliner has a great turning circle and will stay 2wd for that reason.
Also you forgot the driveline maintenance added with 4WD. You have transfer case with bearings, seals and uni joints. A driveshaft with uni joints, the axles and in some cases the unis/CV's in them. Plus the added unsprung weight affects the level of damping/suspension required.