I've had both so some real-world experience....
I bought a new 1976 GMC Vandura "Terravan" conversion in June of 1976. 400 small block, TH350 tranny, full-time 4wd. And drove this thing all over the country but primarily the back roads of Nevada and Utah for 32 years. One of the first changes was to install a Rough Country part-time kit in the transfer case, then remove all the California smog stuff and install an Edelbrock intake and Holley carburetor which brought my fuel mileage from 8 mpg to 12 mpg. Yes, it was unit-body construction which was very rigid - no body twist at all when I had it in a twist and one front wheel and one back wheel was off the ground. But that "frame" under it was not very strong - after about 10 years of rough dirt roads I had to have reinforcing plates welded to the frame where the transfer case mount bolted up because it was cracking. I drove this thing, generally hauling a dirt bike and camping out in it, for 32 years.
In 2007 it became evident I needed to either completely rebuild this old workhorse or get something newer. I wanted a diesel for the better fuel mileage so I started doing some research and really liked what I read about the GM 3500 vans with the Duramax engine. By the way, people assume that because the GM vans can be equipped with a Duramax, they also come with the Allison tranny behind it. Not so. That tranny is too big to fit underneath the van body so the diesel GM vans get a version of the Hydramatic. I found one of the van convertors in Oregon who was at the time converting a Chevy van so I went to take a look. The guys there told me they would convert a GM van to 4x4 but only under protest. Two reasons. You ended up with a GM van with a lot of Ford parts so getting it serviced was a problem. The other was - even though the GM van was now built body on frame, the frame was not nearly as rigid as the Ford. They had a deep ditch on their lot where they could test a rig's resistant to twist when crossing that ditch at an angle, and also check on how the suspension worked. The Chevy van's frame twisted so badly that the front bumper actually made hard contact with the body of the van. The Ford van, on the other hand, did not exhibit any noticeable twist and that decided it for me. I became a Ford van man. I used to have some photos of the vans crossing that ditch but can't find them right now. This is what I have been driving since 2008. I love everything but the fuel mileage (V10, won't buy a Ford 6.0 diesel). Now maybe the GM frame under the vans has been beefed up since 2007, I don't know.