If the vehicle is a F350 dually with a "regular" front Dana 60 and a spacer it is, as referred to above, easy; simply remove the front spacer and use normal wheels.
However, the newer F550s use the Dana "super 60" front axle. There's a good article in the recent Petersen's 4 Wheel & Offroad June 09. The Super 60 has a different, wider hub. However, it can be replaced using a F350 hub and unit bearing. But that will cause the front to be 8 bolt instead of 10 bolt. Perhaps Dynatrac can be of some help in this? Call them and describe the issue, they may be able to supply or make the necessary part, to use low or zero offset wheels in order to run 35-42" singles. Sizes to look at: 285/70R19.5, 305/70R19.5, 335/80R20 (Michelin XZL 141K, Continental MPT81 147K), 13/80R20 (Michelin XZZ, 8000 lb, 41.2", undoubtedly unobtainium, obsolete), Michelin 10.00R20 XZY-2, 147K.
Note I am not listing any 22.5s. As I have stated before, the only functional (non-cosmetic) reason to run "super" singles is offroad ability. 22.5s in the sizes appropriate for a F550 have sidewalls too short to be useful in this area. For example, a 255/70R22.5 has only a 7" sidewall and a 60 sq in footprint. Even a 305/70R22.5 has a 8.4" sidewall and at most 84 sq in footprint. A 335/80R20 has a 10.3" sidewall and a 109 sq in footprint. You want the smallest rim so you get the most "squash" at lower psi.
Charlie