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It's probably cheaper to go to 22.5 inch rims and heavy truck tires. Lots of choices here. As the tires get taller, you'll definitely need to to re-gear your differentials so you don't reduce power too much. Re-gearing will lower your top speed, but you probably don't want to drive a 20,000 lbs vehicle much over 65 anyway.
One further concern is the rear axle length. Almost all medium trucks are designed with dual rear wheels in mind. They have a shorter rear axle so the extra rear wheels don't stick out so far. If you switch to single rear wheels, the rears don't ride directly in the tracks of the fronts. If you want the tires to line up, you might be tempted to use a spacer to move the rears out a little. This raises problems with increasing the load on the rear axle bearings. So a better solution is a longer rear axle.
Chip Haven
Jim, why did you switch to singles? What are you going to do on the back? Thanks
Don
Jim-
Could you describe what bits and pieces you changed to get the ft & rr tracks to line up. I'm thinking of doing the same thing to mine. Was yours a dually pickup, or a cab & chassis?
Scott