Sure. In my first set of drawers the floor in the set was open. I used turn buckles in the corners. That worked pretty well. In the new set the floor is solid. I removed the third row seating mounts and used those threaded points to secure the drawers to the truck with large fender washers and bolts.
The clam shells are are mounted horizontally to the drawer set with 1/4" T nuts, and vertically to the second row seating hardware positions. I removed the seat hardware from the floor of the truck and used those mounting points with large fenders and bolts.
What this has done is secured the entire drawer set in a half dozen spots to the vehicle itself. It doesn't rattle at all. I am not worried a bit about the safety of what I have put in here becoming a weapon in a roll or collision.
Cheers,