A C&C would be an easier platform to build that on plus all of the other advantages that come with a C&C (if it were a 550).
Even the F350C&C can have some advantages over the F350 PU.
One might argue (I won't
) that the C&Cs are designed to haul whereas the PUs are maximised for towing. Certainly the F350 C&C shares much of the same architectural design - not frame thickness tho - as it's bigger brothers.
Regardless, the C&C gives an extra foot of frame to work with and the deck has the potential to be at a lower load height. If if an owner won't be using the PU under frame spare tire location (37s for eg) that length could be useful for sorting the "where to put the spare tire" headache.
If they add under-deck boxes to that flat deck there is about 4" more space between the cab and axle, the truck frame is narrower and the leaf spring pack about 11" shorter. All that adds up to more real estate for storage boxes.
Speaking of leaves, mine had 10 vs 3-4 for the PU version. A HD pack that was easier to alter if too stiff and provides more friction dampening.
Big one for me was the ability to add an aux fuel tank between the frame rails. Easy aftermarket for diesel. Harder, but I think (hope !) doable for gas. Not cheap tho, unless it's a dually, then it's just tick off the factory order option box. Others like to carry J cans, that's OK.
In my time the axle gear ratios were a bit lower also and a few other goodies that might not apply now. The standard equip package on the C&Cs might be beneficial for some - for eg. dual alts for gas.
Anyway, my .02, it's all depends on what the OP's application and wants, PU vs C&C.
I for one won't rain on their parade like some might (not you Andy) I mean ... guys getting a brand new truck and a custom deck, c'mon be happy for the him !