So here's a data point for you:
2018 F150 XLT CCSB, 3.5/10 speed. 3.31 rear end with 7,000lb GVWR package.
XTR package (a Canadian package that includes chrome bumpers and door handles as well as wheels)
Also has the FX4 package with bigger tires and E-locker
Swapped tires in January and went up one size, from 275/65/18 to 275/70/18 (same width but about 1" bigger diameter.) Tires are General Grabber ATX
Towing package with trailer-backup control (never used because I already know how to back up a trailer) and built in trailer brake control (which is great! No more knee buster hanging below the dash.)
This is my DD and also our tow vehicle for a travel trailer (~3900lb R-Pod 179.) However, I've been working at home since March of 2020 so the truck mostly gets driven either on weekend/home depot type runs, or on long trips pulling the trailer.
This year we did a total of 15 camping trips at sites ranging from 36 miles away to 500 miles away. Towing total was around 6,000 miles.
In that time my overall average was around 11 MPG. Now, keep in mind that a lot of that was towing a trailer, and also that I live in Colorado where pulling the trailer over an 11,000' pass is something I might do twice in a weekend.
Non-towing MPG seems to run 15 - 17 for the most part, but again I'd point out that I'm mostly doing suburban or around-town driving. We don't do a lot of long trips in the truck.
I'm scratching my head trying to figure out how so many folks here are getting these great MPG numbers. Mine have been a little bit disappointing. Yes, there have been one or two trips where I've gotten 20 MPG but only under absolutely ideal conditions.
Back when I was driving to and from work every day (10 mile commute each way) I rarely got better than 16 MPG (which is still respectable for a full-sized crew cab truck and is still a significant improvement over the ~12 - 13 MPG I was getting on the Suburban under the same driving conditions.)
On the occasions where I take a long drive in the F-150 WITHOUT the trailer, 18 MPG seems to be about the best I can do. Sometimes it will creep up to 19 but it doesn't stay there long.
On a recent camping trip to Kansas, of all places, I got the worst MPG I've ever gotten in the truck. On flat Kansas roads bucking head- and cross-winds, I had two tanks where I barely got 6.5 MPG. Obviously pulling a trailer in the wind is one of the toughest things to do but to say I was disappointed in the MPG numbers would be an understatement. Even my Suburban, towing under similar conditions, could eke out 8 or 9 MPG.
I typically run 87 octane fuel (which is mid-grade around here) per the owners manual. If I'm towing the trailer I will usually try to get premium (91 octane in the Rocky Mtns) but that hurts when you're filling a 36 gallon gas tank. So far my most expensive fuel up was $115 but on the aforementioned trip to Kansas, I fueled up twice in one day for around $90 EACH TIME. That's $180 for one day of driving 500 miles.