My prior, recent experience was with a FWC Hawk and then Raven on a Tundra with the typical, internal eyebolt tie-downs. Both worked okay once I got the turnbuckles really tight, then there was less or no loosening.
With my current Hallmark Milner on a '14 Ram 2500, I chose a mix solution which I'm quite happy with thus far. The front uses the HappiJac anchor system across the front of the bed, but the "turnbuckles" are Torklift Fastguns. In the rear I chose simple, tidy, internal blot-down through the camper and truck bed.
Over many miles of technical 4WD terrain recently in May, including some rough use (tossed camper contents), and lots of more tame off-highway travel, the combination has worked well for me. I've only had the camper off/on once, but was surprised that lining up the bolts and holes in the rear was not more difficult than it was. However, it was certainly nice to have a helper pushing the hovering camper when inserting the bolts.
For my use, I knew I didn't want to use the TorkLift frame anchors (rock magnets) nor the HappiJac system in the rear.