Fuso owner here, ran Toyo M/Ts for about 60,000 miles, then switched over to the Toyo M/T III. It was like dying and going to heaven. No more flat spotting, no more balancing problems, no more noisy tires and they perform much better in snow and ice. Off road there is no difference in performance between the two tires that I can tell.
My main problem with the M/Ts was that the massive lugs on the front tires would wear on the outside from turning right and left and that would cause a misbalance within 5,000 miles. My tire guy loved me. $ every 5000 miles for a rotate and balance. Fast forward to today. I just completed a 15,000 trek on my M/T IIIs and I had ZERO balance and zero wear problems.
And like others have said, pay attention to heat build up. I have an inside the tire TPMS and watch for heat and pressure buildup especially in summer. When I'm full of diesel and water, I weigh in at just over 13,000#. Traveling too fast (65 mph+) on a highway when it's over 90 degrees could cause problems. Simply pay attention to your equipment. Big trucks are not sports cars. Take it easy, it's the voyage not the destination.