The farthest I can compress the sprinters brake pedal is about 1.1-1.2" which is 2.8-3cm. Assuming another 20% of travel that nets 3.4-3.6cm of MC travel. So its looks feasible. It will be close though. The larger sprinter MC would get the apply distance down to 2.76cm.
Brake balance is going to be affected significantly. The rotors are ~12% larger diameter, and the pistons are 21.6% larger. So net brake bias will be shifted 36% more towards the front. Currently the brake bias is somewhere around 60/40. So with the GM rotors that will become around 75/25? The sprinters ESP/ABS system is brake bias aware, and during heavy braking events will reduce rear brake force to prevent oversteer/spinout. Its a dynamic calculation though, so it just calculates the apparent weight transfer/brake force using the pitch rate and possibly yaw rate when turning.
For long descents, The GM front brakes have about 3 times the heat rejection ability as the MB rears, so that level of balance should be acceptable for preventing one axle from overheating/fading before the other.