No, I didn't do the motor work on my truck. With the EGR gone out, I kept the engine cool with refilling the radiator with water. I had continued towing my Jeep back home to a recommended Ford Tech from a friend. I had the River City delete kit. In review, its probably not hard to get done, but it took 4.5 hrs to go 180 miles keeping the engine cool. I would pull over once I saw the stock temp gauge rise. Let it cool down enough to pour water back in. Then go again.
I think my truck's biggest issue was the injectors themselves, though no issue was scene with analyzers. I had smoking issues at start up (real cold days), heavy diesel smell (warm days), etc.
Other issues for 6.0 owners is the temp difference between oil cooler and water temp. You can get a set of gauges for that or use a plug-n-play digital setup. Many tuners on the market plug into the ECM and provide monitoring gauges with no tuning. Supposedly difference in temp greater than 8-10* creates issues. Computers are all over today's diesel trucks. The programs within those computers direct the operation of the engine.
As others have mentioned, there are other issues on the 6.0. Schafering wiring on the motor grounds/shorts the wire. Turbo has variable vanes and at times, these will get a residue on them restricting the movement. Same for the intake plenum walls gaining residue and restricting the air flow. Exhaust leaks from the manifolds off the heads appears to be gaining popularity.
For the basic upgrades on the 6.0, I would add a EGR delete kit, add cat delete kit and open the exhaust for lesser backpressure(wouldn't run straight pipe). Head bolts/studs if you tow, add hp/torque numbers with tuner, tow heavy loads, etc. Keep oil clean with the micro-filter system, Same for the coolant system. Change out the stock coolant (Ford's) and go with Extended-Life Coolant (ELC) with non-mineralized water. Good set of electronic gauges with a large screen to watch, water temp, oil temp, boost, EGT, fuel pressure. Swap in some banjo bolts for the 6.4l into the 6.0l fuel lines into the head. I would look into the fuel filter system as well since the injectors tend to generate issues and its usually related to the fuel instead of the oil pressure. You really want to keep the oil clean as its the power for the injectors.
I'm done with the 6.0l unless I can get it at the price I want it at. I would do a history search as well as take it to a diesel tech for eval and have them do an engine analyzer test. Just don't forget to review in detail the driveline as well. Balljoints, ujoints, and front suspension bushings tend to take wear. Shocks and brake rotors are a big thing as well with a lot of weight up front and little in the back (pickup).