Another trip...can't wait to watch for your trip reports & photos. With your level of experience and common sense, a solid AWD vehicle, and a good folding shovel you should be good to go.
Just some random roads and POI's most will have mentions/reports on this site for more details:
1: A great I-10 break: RT90 East between Gulfport and Biloxi Mississippi. Great old homes, coastal sights, seafood joints, and you can open your right door and dip your toes in the Gulf.
2:
Natchez Trace Parkway
3:
Skyline Drive
4: The area/roads along the St. Lawrence River (US or Canada) and very nice & scenic. The small communities along "the river" are most interesting & welcoming.
5: Old Town Quebec is stunning and full of flavor and is the next best thing to a trip to France. Fantastic walking areas, shops, museums. Have tea at the Le Chateau Frontenac.