This should be fun. I will throw my engineering education at this one also.
It is true, that aluminum has a finite fatigue life. If aluminum has cyclic forces flowing through it, it will eventually break. Aluminum can not be designed strong enough to escape this issue. But these forces have to be cyclic in direction.
The key point here is the forces must cycle in multiple (at least two) directions, through the material. Forces flowing stronger and weaker, in the same direction is not going to cause the same fatigue problems.
At first glance, these adapters may seem to have cycling forces running through them. This may not actually be true. Here is why. There is a tremendous compressive force being placed on the aluminum adapter, when the lug nuts are tightened down to 80 ft-lbs. For the forces to cycle, the loads on the adapter must overcome this compressive force, and create a force in another direction. Again, aluminum will not crack from fatigue, if the forces are stronger/weaker, but always in the same direction.
The two faces of the adapters have compressive forces placed on them, with the torquing of the lug nuts. One set is clamping the adapter to the hub, and the other set is clamping the wheel to the adapter. There is at least a 1/4" thick section of the adapter that is trapped between the lug-nut-seat and the stud seat. This 1/4" this piece of material is also being compressed by the lug torque forces.
Unless these compressive forces can be unloaded some how, it will be very difficult to change the direction of force through the adapters. The compressive forces may increase and decrease; but they should always be compressive, and therefore not cyclic.
Serious problems would arrise, if any of the lug nuts is not maintaining proper clamping force. Say 50 ft-lbs instead of 80 ft-lbs of torque. The clamping force and therefore the lug torque
must be maintained.
These torque and force ideas are the same principles applied to aluminum heads, connecting rods, etc. This is nothing new, and well understood in the automotive industry.
Just another aspect to think about.