OP either the 400, 800, or 900 k2500 will give you a seriously stout platform to start with. The underpinnings of the gmt800 and 900 are exactly the same. On the 400 youll find either the 5.7, the 7.4 or a 6.5 diesel. The 800 will get a 6.0 or 8.1 and 900 will have the 6.0. None of the 2500s have the stupid emissions valvetrain crap that later 1500s have. Some people will try and say the 5.3 can be tuned to match the 6.0 or 8.1 which is laughable. It may put out similar max hp and torque numbers as the 6.0 but if you look at the rpms needed to generate those numbers on the 5.3 compared to the 6.0 youll see the joke. Comparing the 5.3 to the 8.1 is just stupid. The 8.1 creates more torque at idle than a tuned 5.3 can at redline.
The 2500s have beefier control arms, much stronger wheel bearings and hubs. If you read all the burb threads youll see the 1500 guys trying to turn them into 2500s with rear axle swaps and even changing out the front diff housing for the larger 2500 version. The 2500s come with the 14bolt semi float or the venerated 14bolt full float. Most 2500 burbs Ive seen have the FF version. The 400s are drum rear but they are massive and work very well. All 2500s have stronger front brake setups with thicker discs which are less prone to warpage under heavy use.
The 2500s (early 90s may have the th400) also all come with the 4l80e trans over the 4l60e (prone to failure under heavy vehicle use. Its what they put in cars) and all the 2500s come with factory trans and oil coolers that the 1500s dont. They also have steering pump coolers. Plus the 2500s have larger fuel tanks.
The worst thing about the 1500s is once you put your family in you dont have much gvw capacity for lots of gear or towing. The best analogy is the 1500 is for soccer moms to take the kids to practice. The 2500 is for dad to take the football team and tow the equipment trailer to the game.