The LC is the only vehicle left in Toyota's North American lineup that has that rugged-from-the-ground-up bloodline left in it. I do realize we're talking about 100 series, and not a FJ80, but still, when compared to a V6 powered, mini truck based, American built design, it seems to me that the LC has the upper hand.
As everyone else has stated, they are vastly different vehicles, from design concept and build quality, to handling and drivetrain.
I can't let this comment go unchecked.
The 4runner is "american" built? Since when? And its mini-truck based? It's a fully boxed frame made specifically for the 4runner and Toyota's LandCruiser Prado platforms across the globe. I think you're confusing the Tacoma, Tundra/Sequoia lineups with the 4runner...those former models are in fact American-built and predominantly reliant on C-channel frames (which is a conversation unto itself).
OP, the LandCruiser is definitely the model with more cache and heritage. That said, I've extensively driven both the 4th gen and 5th gen 4runners....they are very good vehicles which require little mods out of the box, the 5th gen more so than the 4th gen. If space and towing, and that extra 1% of toughness is what you want, yes go with the the LC 100. If you want a better bargain with nearly the same capability, get the 4runner...let's face it, a 4th gen with a v8 has a lot of what the LC 100 is offering: solid rear axle, IFS, V8 torque, boxed frame. The 4th gen does have more of a car-like feel in stock form, but they do take very well to suspension mods.
Either way, you can't go wrong. Both are great vehicles.