The guys from Centramatic told me they can cure imbalance but nothing can cure out of round. That might be your problem.
The guy that originally balanced them checked that after he started having problems, and I asked the Ford dealer to check it also, but I don't know if they really did or not.
No lift on the truck, just what came from the factory. Everything is stock, except I replaced the worn out OEM shocks with Monroe's a couple of years ago.
Even though I bought the tires in 2011, they only have about 6,000 or 7,000 miles on them. I had a SUV I drove most of the time until last year when I sold it. Now I drive the F250 regularly. The vibration has been there since day one, but the start and stop mph range did shift up a few points when I had the tires rebalanced at the dealer.
While it was at the dealer, I told them to check everything including u-joints, bearings, etc. and they said it was all OK. I don't think they checked the rear driveline though.
But enough derailing! One more question and I'll get off of here...
I have the switch on the dash to engage the 4WD, which I hate. I have not really had this truck off road, and that's not what I bought it for. However, my yard angles down sharply towards the curb and on several occasions I have used 4WD to back up the incline to my storage building. The last time I did I noticed my back wheels spun, but the front did nothing even though the dash lights indicated it was in 4WL. I haven't checked the vacuum lines yet, but will soon.
I have rebuilt dozens of warn locking hubs before, so I'm somewhat familiar with how the Ford Auto/Manual hubs work also. Most of the time they either work or they don't and something is trashed inside. So, is there anyway a defective hub could be causing the vibration at 40-50 mph range, even though there is no indication like heat or noise, that anything is wrong with them?
I wish I had another set of tires and rims that I know are good, to test it with and that would narrow it down pretty quickly.