Jay, as a longtime roadie I used to be hyper-geeked on my bike setup. I measured my bikes to the nanometer. While racing at the National Championships several years ago, my time trial bike got the cranks damaged in transit. I went to a local shop, plopped down $500 for new cranks on my $10,000 speed machine and the day was saved. I placed okay, but broke a personal 40K record. I continued to kick *** on that bike for two years before I realized one crank was 172.5mm and the other 175mm. I had no clue.
So much for me being super sensitive to tiny differences in bike metrics. LOL.
Now that I have this gig whereby I ride a dozen different bikes in a year, I just hop on, get the seat relatively where it should be, spend a few weeks settling in, and wouldn't you know it, 90% of the time the bike works out great. So, while I do tend to still scrutinize the millimeters and angles, it's not until I spend a month on a bike I can really put it all together with an overall evaluation.