Of all of the bikes ive ridden, a KLR650 is probably the best bike I have ridden. I have suggested it to many people. Its light for what it is, its very soft, it has great brakes (08+) its not real tall, you can easily stand up on it, aftermarket support is that of a chevy 350 (meaning there are tons of companies selling parts for it) and its very easy to maintain. Resale value should you not be interested in it is great. Should you end up liking it, you could travel the world on it.
Im gonna throw out another vote for the KLR650, for all of the above reasons, plus a couple more. First, its a great "mid-range" bike. After riding the KLR for a bit, youll know if you want smaller, bigger or good right there. Second, theyre CHEAP to maintain. If (when) you drop it, youre not going to be having panic attacks when thinking about repair costs.
Considering youve never ridden before, Ill also throw out another vote for an MSF course. Personally I think learning on the dirt is the easy part. Depending on how you want to ride, you may never really "test" the limits of traction. Then again, you could grow into wanting to do just that. You could be like me, and just putter around enjoying the scenery as seen from two wheels. On the street however, like someone else said, its not about you...its about all the cages around you. Riding on the steet is comparatively easy. Fairly smooth, normally good traction, etc. The hard part is watching out for granny who cant see over her steering wheel, or Junior texting his buddies while at the same time hes pulling out of a parking lot onto the street and never noticing you coming at him.
The only comment I will wholeheartedly disagree with is new riders getting ABS. In a car/truck its fine. On a bike I see it as a MAJOR crutch to learning to ride. Once someone learns to ride, knows how to safely brake (normal, panic or otherwise), then by all means get ABS. The problem with starting out with ABS is that you will not be able to learn how to ride without it. Theres a big difference between panic braking with and without. Yes, you will be able to learn to ride a little more safely, but the first time the ABS goes out (blown fuse, broken wire, etc.) youre going to be in trouble. And according to Murphys Law, thats when a car will pull right out in front of you and youre going to have to panic stop, without ABS AND without the knowledge of how to safely use your normal brakes to their full potential.
Take it for what its worth. Just my $.02