I'm a new guy here so take me for the village idiot I am but here goes....
I've got a 4th Gen 4Runner based on the T120 platform - very different beast than the 3rd Gen 4Runner. I picked it up to be the family adventure mobile now that our little boy is nearing 2.5 years old and we can get back out and doing stuff.
My wife and I took my old 97 Wrangler (bought new from the showroom floor 15 years ago) all over the country on roadtrips. It was tough at times, I won't lie. But we blasted that thing to the Grand Canyon, West Virginia, etc. and had some of the best times of our lives in it. I think part of what makes a good 'expo rig' comes down to what a person is willing to do without (see the biker dudes and minimalist backpackers). The more room you have, the more stuff you'll take. Just the way it goes.
Well, we had a little boy and as much as I loved my Jeep - it just doesn't cut it once you have more than 2 people (for us) and you don't want to have to deal with a trailer/rack all the time. So, I started looking around. The 100 series LCs are awesome. However, I quickly learned that I could get the exact same power train; 2UZ-FE V8 and A750F 5 speed. So, I decided to compromise on space and try a 4th Gen T4R. The good part is since the vehicle is smaller the gas mileage goes up.
I've still got Toyota reliability, roominess and something the Jeep didn't have - AC!!. Easy to start feeling spoiled.
I love my 4Runner. While I fantasize about taking off for Argentina (and I just might someday) I think the T120 platform is great for cross country driving in the U.S. I don't know how common 100 series 2UZ-FE drivetrains are in S. America (I'm the village idiot, remember) but I'd bet drivetrain parts wouldn't be too bad. Suspension/Electrical stuff might be harder to source...
I will say the highway MPG on my 4Runner really starts to go down over 70mph. We took ours to Missouri this summer and going 80-85 through kansas there were times it was down to 15.5 MPG. Was really hoping for some of that 19MPG. But, the Jeep certainly couldn't have been getting better. Funny thing: I never ever once in 15 years paid attention to the MPG I got in my Jeep. I just knew it got around 300 miles to the tank and I'd fill it up when it got empty. Different times....
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aka boondoggle
2004 Toyota 4Runner V8, ~107k miles